T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling
S. S. Chin, E. Guillen, L. Chorro, S. Achar, S. Oberle, K. Ng, F. Alfei, D. Zehn, G. Altan-Bonnet, F. DELAHAYE, G. Lauvau
This study shows that TCR and IL-2 signaling strength during vaccination epigenetically programs memory CD8+ T cell functional fitness through chromatin remodeling.
bioRxiv · Oct 19, 2021Immunology