G. Lauvau

The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1alpha-dependent recruitment and differentiation of pro-tumor ICOShiGITRhi Blimp-1+ effector regulatory T cells in breast tumors

This study shows that MLL3/TP53/PIK3CA mutations in breast tumors promote immunosuppressive Treg cell differentiation via HIF1alpha, leading to tumor growth and suggesting therapeutic targets.

Chemoenzymatic Measurement of Cell-surface Glycan in Single-cell Multiomics: LacNAc as an Example

The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.

CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice

This study shows CD169+ macrophages are essential for plasmacytoid dendritic cell arrest and type I IFN priming in malaria-infected mice through TLR7 and STING sensing.

T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling

This study shows that TCR and IL-2 signaling strength during vaccination epigenetically programs memory CD8+ T cell functional fitness through chromatin remodeling.

Cytolytic memory CD4+ T cell clonotypes are expanded during Plasmodium falciparum infection

The paper identifies clonally expanded cytolytic memory CD4+ T cells in Plasmodium falciparum malaria patients and links their reduced chemotactic and inhibitory receptor expression to clinical immunity.

Memory CD8+ T cells mediate early pathogen-specific protection through localized delivery of chemokines and IFNγ to clusters of inflammatory monocytes

This study shows memory CD8+ T cells use cognate antigen to rapidly produce chemokines and IFNγ in splenic monocyte clusters, providing early pathogen protection before clonal expansion.

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses

This study shows that blocking LAG-3 in PD-L1-deficient mice improves blood-stage malaria clearance without relying on humoral immunity.

Listeria monocytogenes virulence factors are secreted in biologically active Extracellular Vesicles

This study shows Listeria monocytogenes secretes biologically active extracellular vesicles containing virulence factors like LLO and PI-PLC, which contribute to cytotoxicity in macrophages.