E. Guillen

The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1alpha-dependent recruitment and differentiation of pro-tumor ICOShiGITRhi Blimp-1+ effector regulatory T cells in breast tumors

This study shows that MLL3/TP53/PIK3CA mutations in breast tumors promote immunosuppressive Treg cell differentiation via HIF1alpha, leading to tumor growth and suggesting therapeutic targets.

T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling

This study shows that TCR and IL-2 signaling strength during vaccination epigenetically programs memory CD8+ T cell functional fitness through chromatin remodeling.

Memory CD8+ T cells mediate early pathogen-specific protection through localized delivery of chemokines and IFNγ to clusters of inflammatory monocytes

This study shows memory CD8+ T cells use cognate antigen to rapidly produce chemokines and IFNγ in splenic monocyte clusters, providing early pathogen protection before clonal expansion.

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses

This study shows that blocking LAG-3 in PD-L1-deficient mice improves blood-stage malaria clearance without relying on humoral immunity.