K. Ng

Optimized dimerization of the PAR-2 RING domain drives cooperative and selective membrane recruitment for robust feedback-driven cell polarization

This study shows that optimized dimerization of the PAR-2 RING domain enables cooperative and selective membrane recruitment, enhancing robustness and responsiveness in cell polarization.

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

Cleavage furrow-directed cortical flows bias mechanochemical pathways for PAR polarization in the C. elegans germ lineage

The paper investigates PAR polarization in C. elegans germline cells, finding that cleavage furrow-directed cortical flows drive symmetry breaking similar to zygote mechanisms.

Design principles for selective polarization of PAR proteins by cortical flows

The paper shows that PAR protein segregation by cortical flows depends on membrane association stability rather than oligomer size, and demonstrates this through experiments and theory.

SAIBR: A simple, platform-independent method for spectral autofluorescence correction

SAIBR corrects autofluorescence in imaging data using a simple, platform-independent method, enabling accurate quantification of weakly expressed proteins across diverse systems.

Broad human and animal coronavirus neutralisation by SARS-CoV-2 S2-targeted vaccination

This study shows that SARS-CoV-2 S2-targeted vaccination induces broad neutralizing antibodies against multiple coronaviruses and provides better protection than homologous boosting.

Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants

This study shows that stenoparib inhibits SARS-CoV-2 variants in vitro, with EC50 values ranging from 4.1 to 24.1 M, and combination with remdesivir enhances antiviral effects.

T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling

This study shows that TCR and IL-2 signaling strength during vaccination epigenetically programs memory CD8+ T cell functional fitness through chromatin remodeling.

RUNIMC: An R-based package for imaging mass cytometry data analysis and pipeline validation

The paper introduces RUNIMC, an R package for imaging mass cytometry data analysis, comparing an unbiased approach with a biased method using synthetic and clinical datasets.

Multiplexed bioluminescence microscopy via phasor analysis

This paper introduces a method combining bioluminescence with phasor analysis to rapidly differentiate multiple luciferase reporters and resonance energy transfer processes in time-lapse imaging.

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

This study compares antibody cross-reactivity between SARS-CoV-2 B.1.1.7 and parental strains, finding reduced recognition and neutralization of older variants after B.1.1.7 infection.

Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

The paper examines antibody responses to HCoV-OC43 and SARS-CoV-2 in children with autoimmune rheumatic diseases, finding stronger spike antibody responses and cross-reactivity despite immunosuppressive treatment.

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

This paper develops an immunogenic mouse model of KRAS-mutant lung cancer that responds to immunotherapy and reveals immune responses target endogenous retroviral antigens rather than neoantigens.

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

This study identifies a transitional cancer cell state in metastatic pancreatic cancer and shows that tumor microenvironment signals drive transcriptional plasticity and subtype transitions.

High-throughput cultivation of stable, diverse, fecal-derived microbial communities to model the intestinal microbiota

This study develops a high-throughput method to cultivate diverse, stable fecal-derived microbial communities in vitro, demonstrating their utility for modeling the intestinal microbiota and predicting in vivo responses to antibiotics.

Emergence of enteroaggregative Escherichia coli within the ST131 lineage as a cause of extraintestinal infections

The paper identifies a new ST131 E. coli sublineage with enteroaggregative traits causing extraintestinal infections and outbreaks in Denmark.

Gut microbiome transition across a lifestyle gradient in Himalaya

The paper examines gut microbiome differences across four Himalayan populations with varying lifestyles, finding that microbiome composition is significantly associated with lifestyle changes rather than genetics or geography.

Toxoplasma gondii infection triggers chronic cachexia and sustained commensal dysbiosis in mice

This study shows that Toxoplasma gondii infection in mice causes chronic cachexia and sustained gut microbiota changes, but not all microbiota alterations are sufficient to cause cachexia.