HIF1a-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia
A. Rasola, C. Laquatra, C. Sanchez-Martin, G. Minervini, E. Moroni, M. Schiavone, S. C. E. Tosatto, F. Argenton, G. Colombo, P. Bernardi, I. Masgras
This study identifies TRAP1 as a HIF1a-dependent regulator of mitochondrial bioenergetics in hypoxic conditions, showing its role in maintaining respiration in developing embryos and cancer models.
bioRxiv · Sep 23, 2020Biochemistry