A. Rasola

TRAP1 and cyclophilin D compete at OSCP subunit to regulate enzymatic activity and permeability transition pore opening by F-ATP synthase

SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: a Computational Model of Epitope Loss in Variants of Concern

This study uses computational models to predict how SARS-CoV-2 spike protein mutations affect antibody binding, showing epitope loss in variants of concern.

Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3

This study shows that neurofibromin loss reduces mitochondrial respiration and NAD+ levels, promoting tumor growth, and that restoring NAD+ or SIRT3 can counteract this effect.

HIF1a-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

This study identifies TRAP1 as a HIF1a-dependent regulator of mitochondrial bioenergetics in hypoxic conditions, showing its role in maintaining respiration in developing embryos and cancer models.

The answer lies in the energy: how simple atomistic molecular dynamics simulations may hold the key to epitope prediction on the fully glycosylated SARS-CoV-2 spike protein

This paper uses energy-decomposition from molecular dynamics simulations to predict epitopes on the fully glycosylated SARS-CoV-2 spike protein, identifying immunoreactive regions validated by experimental structures.

S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli

This study shows that S-nitrosylation of TRAP1 at Cys501 alters its structure and ATPase activity, affecting cell response to apoptotic stimuli.

Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+-dependent death of cancer cells

The paper shows that displacing HK2 from MAMs triggers Ca2+-dependent death of cancer cells, offering a potential anti-neoplastic strategy.