How Aberrant N-Glycosylation Can Alter Protein Functionality and Ligand Binding: an Atomistic View
M. Castelli, P. Yan, A. Rodina, C. S. Digwal, P. Panchal, G. Chiosis, E. Moroni, G. Colombo
The paper investigates how N-glycosylation of GRP94 modulates its conformational dynamics and ligand binding, providing insights for designing inhibitors targeting disease-associated conformations.
bioRxiv · Dec 22, 2022 · PreprintBiochemistry