F. Baumdicker

Effectiveness of CRISPR-Cas in Sensitizing Bacterial Populations with Plasmid-Encoded Antimicrobial Resistance

This study evaluates how CRISPR-Cas plasmids can sensitize bacteria with plasmid-encoded antibiotic resistance to conventional antibiotics, finding that DNA cleaving is effective for low copy numbers and gene silencing for high copy numbers.

Neural Networks for self-adjusting Mutation Rate Estimation when the Recombination Rate is unknown

This paper uses neural networks to estimate mutation rates in population genetics, showing they can match model-based methods for low/high recombination and outperform them for intermediate rates.

Horizontal gene transfer-mediated bacterial strain variation affects host fitness

The paper identifies horizontal gene transfer in bacterial strains affecting Drosophila host fitness through thiamine biosynthesis pathway variation.

A community-maintained standard library of population genetic models

The paper introduces stdpopsim, a community-maintained library for population genetic models, to standardize simulations and facilitate benchmarking of inference tools.

panX: pan-genome analysis and exploration

panX is a pipeline and visualization tool for analyzing pan-genomes, enabling exploration of gene clusters, phylogenetic trees, and evolutionary history.