Effectiveness of CRISPR-Cas in Sensitizing Bacterial Populations with Plasmid-Encoded Antimicrobial Resistance
J. Kippnich, F. Benz, H. Uecker, F. Baumdicker
This study evaluates how CRISPR-Cas plasmids can sensitize bacteria with plasmid-encoded antibiotic resistance to conventional antibiotics, finding that DNA cleaving is effective for low copy numbers and gene silencing for high copy numbers.
bioRxiv · Jul 5, 2024Evolutionary Biology