F. Beier

Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model

This study shows that aged PANX3 knockout mice develop severe primary osteoarthritis, suggesting PANX3 deletion harms joint health in aging.

Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

This study shows that deleting Panx3 in mice leads to increased knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

Anabolic phenotype in cartilage-specific Mitogen-inducible gene-6 knockout mice is independent of Transforming growth factor-α

This study shows that cartilage-specific Mig6 knockout mice exhibit anabolic cartilage changes and chondro-osseus nodules independent of TGF-α levels.

Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner

This study shows that PANX3 deletion reduces fat mass and inflammation in male mice but not females, with male KOs having fewer adipocytes and lower inflammatory gene expression.

A feedback-loop between telomerase activity and stemness factors regulates PDAC stem cells

This study shows that telomerase activity and stemness factors form a feedback loop that maintains pancreatic cancer stem cells, and disrupting this loop reduces their tumorigenic potential.

Overexpression of Mig-6 in Cartilage Induces An Osteoarthritis-Like Phenotype In Mice.

This study shows that overexpressing Mig-6 in cartilage leads to accelerated osteoarthritis in mice during aging without major developmental issues.

Liver X Receptor activation regulates genes involved in lipid homeostasis in developing chondrocytes

This study shows LXR activation affects lipid metabolism genes in chondrocytes, altering cholesterol efflux and chondrocyte behavior.