C. Brooks

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.

Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model

This study shows that aged PANX3 knockout mice develop severe primary osteoarthritis, suggesting PANX3 deletion harms joint health in aging.

Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

This study shows that deleting Panx3 in mice leads to increased knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody

This study characterizes the hierarchical epistasis between heavy and light chain mutations in an anti-influenza bnAb, showing how such interactions shape the evolution of broad antigen affinity.

Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein

This study investigates how multivalent binding of dynein light chains regulates the interactions of dynein intermediate chain with dynactin and NudE, revealing autoinhibition caused by intramolecular interactions.

A computational model of fractal interface formation in bacterial biofilms

The paper presents a computational model of bacterial biofilm interface formation, showing fractal patterns emerge from cell-level interactions and mechanical forces.

Characterization of enterovirus D68 infection in four nonhuman primate species

This study infects juvenile nonhuman primates with EV-D68 isolates and finds limited viral shedding and no neurological disease, suggesting the need for model refinements to study AFM.