Structure of a HIV-1 IN-Allosteric Inhibitor Complex at 2.93 Angstrom Resolution: Routes to Inhibitor Optimization
G. Eilers, K. Gupta, A. Allen, S. Montermoso, H. Murali, R. Sharp, Y. Hwang, F. Bushman, G. Van Duyne
The paper reports the X-ray structure of an HIV-1 IN-ALLINI complex, identifying pi-mediated interactions that guide inhibitor optimization.
bioRxiv · Jun 9, 2022Biochemistry