A. Allen

Loss of tight junction protein claudin 18 uncovers alveolar epithelial stem cell plasticity and emergence of non-fibrogenic transitional progenitors

The paper identifies regeneration-associated transitional progenitors (RATPs) in Cldn18 knockout mice, showing they are less fibrogenic and contribute to lung repair rather than fibrosis.

Ankyrin-B is required for the establishment and maintenance of lens cytoarchitecture, mechanics, and clarity

This study shows that ankyrin-B is essential for maintaining lens clarity, structure, and mechanics through its role in cytoskeletal and membrane organization.

Design of High Affinity Binders to Convex Protein Target Sites

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

Alcohol-Induced Mucociliary Dysfunction: Role of Defective CFTR Channel Function

This study shows chronic alcohol use reduces CFTR activity and airway surface hydration, impairing mucociliary clearance and increasing respiratory infection risk.

A DNA Unwinding Equilibrium Serves as a Checkpoint for CRISPR-Cas12a Target Discrimination

This study investigates Cas12a's target discrimination mechanism, revealing a DNA unwinding equilibrium as a checkpoint for mismatch sensing before cleavage.

Nucleotide metabolism is linked to cysteine availability

This study investigates how erastin and other ferroptosis inducers affect global metabolism, finding that nucleotide metabolism is significantly impacted and linked to cysteine availability.

Improving de novo Protein Binder Design with Deep Learning

This paper improves de novo protein binder design by using deep learning models to assess design success rates and computational efficiency.

Structure of a HIV-1 IN-Allosteric Inhibitor Complex at 2.93 Angstrom Resolution: Routes to Inhibitor Optimization

The paper reports the X-ray structure of an HIV-1 IN-ALLINI complex, identifying pi-mediated interactions that guide inhibitor optimization.

Downtown Diet: a global meta-analysis of urbanization on consumption patterns of vertebrate predators

This study analyzes how urbanization affects predator diets globally, finding that dietary diversity and nitrogen ratios remain similar, but carbon consumption increases, with no significant effect from human footprint intensity.

Phylodynamic analysis of an emergent Mycobacterium bovis outbreak in an area with no previously known wildlife infections

The paper analyzes an M. bovis outbreak in cattle and badgers using mathematical modeling, machine learning, and Bayesian methods, finding a single introduction from Northern Ireland and two-phase transmission dynamics.

Plankton Planet: 'seatizen' oceanography to assess open ocean life at the planetary scale

Plankton Planet uses citizen science to collect global plankton biodiversity data via DNA barcodes, achieving comparable quality to Tara Oceans with a scalable, open-access approach.

Global shortfalls in extinction risk assessments for endemic flora

The paper assesses global extinction risk for endemic plant species, finding that 67% of country-based endemic species lack risk assessments, despite urgent conservation needs.