Y. Hwang

Ephrin Forward Signaling Controls Interspecies Cell Competition in Pluripotent Stem Cells

This study identifies Ephrin A ligands in mouse cells as mediators of cell death signaling to human pluripotent stem cells during interspecies co-culture, enhancing chimera formation when inhibited.

Regulation of fatty acid delivery to metastases by tumor endothelium

This study identifies a mechanism by which tumor endothelium regulates fatty acid delivery to metastases, showing that mTORC1 inhibition in endothelial cells reduces metastatic disease by impairing T cell fatty acid uptake.

High-Resolution Spatial Transcriptomic Atlas of Mouse Soleus Muscle: Unveiling Single Cell and Subcellular Heterogeneity in Health and Denervation

Flagellar motor remodeling during swarming requires FliL

This study identifies FliL as essential for flagellar motor remodeling during swarming in diverse bacteria, showing conservation across species and a specific interaction with FliF.

Direct quantification of unicellular algae sinking velocities reveals cell size, light, and nutrient-dependence

The paper quantifies sinking velocities of unicellular algae to show their dependence on cell size, light, and nutrients, revealing mechanisms linking cell composition to vertical movement.

A developmental program that regulates mammalian organ size offsets evolutionary distance

The paper identifies a conserved molecular program regulating organ size across species, showing higher homology in humans and pigs than in closely related mice.

A Second Role for the Second Messenger Cyclic-di-GMP in E. coli: Arresting Cell Growth by Altering Metabolic Flow

This paper identifies a new role for c-di-GMP in E. coli where YfiN inhibits cell growth by altering metabolic flow, independent of its usual division inhibition function.

Structure of a HIV-1 IN-Allosteric Inhibitor Complex at 2.93 Angstrom Resolution: Routes to Inhibitor Optimization

The paper reports the X-ray structure of an HIV-1 IN-ALLINI complex, identifying pi-mediated interactions that guide inhibitor optimization.

NMR as a readout to monitor and restore the integrity of complex chemoenzymatic reactions

This paper uses NMR to monitor and restore the integrity of a complex chemoenzymatic reaction by assessing reagent integrity and reaction progress.

Efflux-linked Accelerated Evolution of Antibiotic Resistance at a Population Edge

The paper shows efflux promotes antibiotic resistance mutations by linking high efflux to reduced DNA repair, validated through a clinical resistome database and swarm experiments.

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

This paper identifies LY-CoV1404, a potent SARS-CoV-2 neutralizing antibody effective against multiple variants, including Omicron and Delta, due to its conserved epitope and resistance to common mutations.

Cocaine receptor identified as BASP1

The paper identifies BASP1 as a high-affinity cocaine receptor, showing its role in cocaine's behavioral effects and suggesting it as a therapeutic target for addiction.

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

LY-CoV555, an anti-spike antibody from a convalescent COVID-19 patient, neutralizes SARS-CoV-2 and protects non-human primates against infection.

Diverse viruses carrying genes for microbial extremotolerance in the Atacama Desert hyperarid soil

The paper identifies diverse viruses in Atacama Desert soils that carry genes for microbial extremotolerance, suggesting a mutualistic role in host survival under extreme conditions.

The Molecular Link Between Auxin And ROS-Mediated Polar Growth

This paper identifies a molecular mechanism linking auxin-regulated transcription factors to ROS-mediated polar growth in root hairs.