Author

R. Sharp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:CITE-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

A. Carr· 2 shared A. R. Cox· 2 shared A. R. Kendal· 2 shared C. Loizou· 2 shared J. B. Felix· 2 shared K. Gupta· 2 shared K. H. Kim· 2 shared M. Rogers· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

A. Carr

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability

P. M. Masschelin, P. Saha, S. A. Ochsner, A. R. Cox, K. H. Kim, J. B. Felix, R. Sharp, X. Li, L. Tan, J. H. Park, L. Wang, V. Putluri, P. L. Lorenzi, A. M. Nuotio-Antar, Z. Sun, , S. M. Hartig

This study shows that vitamin B2 deficiency impairs PPAR regulation of fasting glucose, and PPAR agonists can rescue this defect.

bioRxiv · Oct 16, 2022Physiology

Structure of a HIV-1 IN-Allosteric Inhibitor Complex at 2.93 Angstrom Resolution: Routes to Inhibitor Optimization

G. Eilers, K. Gupta, A. Allen, S. Montermoso, H. Murali, R. Sharp, Y. Hwang, F. Bushman, G. Van Duyne

The paper reports the X-ray structure of an HIV-1 IN-ALLINI complex, identifying pi-mediated interactions that guide inhibitor optimization.

bioRxiv · Jun 9, 2022Biochemistry

Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects

A. R. Cox, P. M. Masschelin, P. Saha, J. B. Felix, R. Sharp, Z. Lian, Y. Xia, N. Chernis, D. A. Bader, K. H. Kim, X. Li, J. Yoshino, X. Li, Z. Sun, H. Wu, , S. M. Hartig

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

bioRxiv · Sep 11, 2021 · PreprintPhysiology

Combined single cell proteomics and transcriptomics reveals discrete human tendon cells populations persist in vitro and on fibrous scaffolds

A. R. Kendal, A. Lach, P.-A. Mouthuy, R. Brown, C. Loizou, M. Rogers, R. Sharp, A. Carr

The paper identifies discrete human tendon cell populations using combined single cell proteomics and transcriptomics, showing some persist in vitro and on fibrous scaffolds, with pro-inflammatory clusters enriched on aligned fibres.

bioRxiv · Aug 9, 2021 · PreprintCell Biology

Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer

K. Gupta, Y. Wen, N. S. Ninan, A. C. Raimer, R. Sharp, A. M. Spring, K. L. Sarachan, M. C. Johnson, G. D. Van Duyne, A. G. Matera

This study identifies a structural motif in the SMN YG box essential for higher-order oligomerization, which is critical for viability and linked to SMA in animal models.

bioRxiv · Nov 7, 2020Biochemistry

Identification of human tendon cell populations in healthy and diseased tissue using combined single cell transcriptomics and proteomics

A. R. Kendal, T. Layton, H. Al-Mossawi, R. Brown, C. Loizou, M. Rogers, R. Sharp, S. Dakin, L. Appleton, A. Carr

This study identifies eight distinct human tendon cell populations in healthy and diseased tissue using single-cell CITE-sequencing, revealing disease-specific changes in cell composition and marker expression.

bioRxiv · Dec 9, 2019 · PreprintCell Biology