Author

F. C. MacKintosh

Primary ORCID profile (0000-0002-2607-9541 · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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F. C. MacKintoshiD4 papers · Center for Theoretical Biological Physics

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

A. Pham· 1 shared A. Roll-Mecak· 1 shared C. F. Schmidt· 1 shared D. R. Kovar· 1 shared J. N. Onuchic· 1 shared K. Nishi· 1 shared M. L. Gardel· 1 shared P. M. McCall· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiophysics

A. Pham

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 26, 2023

Nonequilibrium bending fluctuations reveal microtubule mechanics in-vivo and their regulation by glutamylation

K. Nishi, S. Raja, A. Pham…·C. F. Schmidt

The paper measures microtubule mechanics in living cells using motor-generated forces and shows that polyglutamylation increases microtubule stiffness.

DOI 10.1101/2023.10.26.564252

imagingstatistical model

𝕏 PostBluesky

BiophysicsbioRxivApr 23, 2023

Temporally correlated active forces drive segregation and enhanced dynamics in chromosome polymers

S. Brahmachari, T. Markovich, F. C. MacKintosh, J. N. Onuchic

The paper models chromosome polymers with active forces, showing activity drives segregation and dynamic compaction, and alters compartmental organization.

DOI 10.1103/prxlife.2.033003

statistical modelchromatin & epigenetic regulation

𝕏 PostBluesky

BiophysicsbioRxivJun 26, 2017

Cofilin Drives Rapid Turnover and Fluidization of Entangled F-actin

P. M. McCall, F. C. MacKintosh, D. R. Kovar, M. L. Gardel

This paper shows cofilin-mediated severing of F-actin accelerates turnover and stress relaxation in entangled solutions, tuning viscosity over two orders of magnitude.

DOI 10.1073/pnas.1818808116

experimental assay

𝕏 PostBluesky