Author

A. Roll-Mecak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:imaging· 1

Frequent Co-Authors

Y. Li· 2 shared A. Akhmanova· 1 shared A. D. Cook· 1 shared A. Pham· 1 shared A. Vemu· 1 shared C. F. Schmidt· 1 shared C. Kim· 1 shared C. Moores· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Y. Li

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The TTLL10 polyglycylase is stimulated by tubulin glutamylation and inhibited by polyglycylation

S. Cummings, Y. Li, J. Spector, C. Kim, A. Roll-Mecak

This study identifies substrate preferences and regulatory mechanisms of TTLL glycylases, showing how tubulin glutamylation and polyglycylation influence TTLL10 activity and microtubule modification.

bioRxiv · Mar 31, 2024 · PreprintBiochemistry

Cryo-EM structures of human α1B/βI+βIVb microtubules shed light on isoform specific assembly

E. A. Zehr, A. Roll-Mecak

The paper reports cryo-EM structures of human α1B/βI+βIVb microtubules in GDP and GTP-like states, revealing isoform-specific sequence variations affecting polymerization interfaces and microtubule dynamics.

bioRxiv · Dec 1, 2023 · PreprintBiophysics

Nonequilibrium bending fluctuations reveal microtubule mechanics in-vivo and their regulation by glutamylation

K. Nishi, S. Raja, A. Pham, R. Freeman, A. Roll-Mecak, F. C. MacKintosh, C. F. Schmidt

The paper measures microtubule mechanics in living cells using motor-generated forces and shows that polyglutamylation increases microtubule stiffness.

bioRxiv · Oct 26, 2023 · PreprintBiophysics

Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes

K. K. Mahalingan, E. K. Keenan, M. Strickland, Y. Li, Y. Liu, H. L. Ball, M. E. Tanner, N. Tjandra, A. Roll-Mecak

This study identifies active-site residues in TTLL enzymes that determine their specificity for initiating or elongating polyglutamate chains on tubulin, revealing structural basis for their functional specialization.

bioRxiv · Jun 7, 2020Biochemistry

Structural determinants of microtubule minus end preference in CAMSAP CKK domains

J. Atherton, Y. Luo, S. Xiang, C. Yang, K. Jiang, M. Stangier, A. Vemu, A. D. Cook, S. Wang, A. Roll-Mecak, M. O. Steinmetz, A. Akhmanova, M. Baldus, C. Moores

This study compares human and Naegleria CKK domains to show how structural differences in tubulin conformations enable microtubule minus-end recognition.

bioRxiv · Mar 27, 2019Biophysics