Structure-guided design of a cell penetrating peptide preventing cAMP modulation of HCN channels
A. Moroni, A. Saponaro, F. Cantini, A. Porro, A. Bucchi, D. DiFrancesco, V. Maione, C. Donadoni, B. Introini, P. Mesirca, M. E. Mangoni, G. Thiel, L. Banci, B. Santoro
The paper designs a cell-penetrating peptide, TRIPnano, that blocks cAMP modulation of HCN channels by competing for binding and inducing allosteric changes, reducing spontaneous action potential firing in sinoatrial node myocytes by 30%.
bioRxiv · Jan 24, 2018Physiology