A. Moroni

HCN channels sense temperature and determine heart rate responses to heat

The paper identifies a conserved motif in HCN4 channels that mediates heat sensing and modulates heart rate responses to thermal energy.

SARS-CoV-2 envelope-protein corruption of homeostatic signaling mechanisms in mammalian cells

This study shows that SARS-CoV-2 envelope protein disrupts cellular homeostasis by forming ion channels, leading to altered Ca2+ and pH levels and membrane depolarization.

X-ray Irradiation activates immune response in human T-lymphocytes by eliciting a Ca2+ signaling cascade

The paper shows X-ray irradiation triggers a Ca2+ signaling cascade in T-lymphocytes, leading to immune activation through NFAT nuclear translocation.

Codon bias determines sorting of ion channel protein

The paper shows that codon bias affects the sorting of ion channel proteins to mitochondria but not the secretory pathway in mammalian cells.

A small viral potassium ion channel with an inherent inward rectification

The paper identifies a small viral K+ channel with inherent inward rectification, distinguishing it from canonical Kir channels by showing rectification is a property of the transmembrane domains.

Structural basis for ion selectivity in TMEM175 K+ channels

This study determines the X-ray structure of a bacterial TMEM175 K+ channel, revealing a unique cation-selective mechanism involving a conserved threonine residue and conformational changes.

Structure-guided design of a cell penetrating peptide preventing cAMP modulation of HCN channels

The paper designs a cell-penetrating peptide, TRIPnano, that blocks cAMP modulation of HCN channels by competing for binding and inducing allosteric changes, reducing spontaneous action potential firing in sinoatrial node myocytes by 30%.