PhysiologybioRxiv
Structure-guided design of a cell penetrating peptide preventing cAMP modulation of HCN channels
A. Moroni, A. Saponaro, F. Cantini…·B. Santoro
The paper designs a cell-penetrating peptide, TRIPnano, that blocks cAMP modulation of HCN channels by competing for binding and inducing allosteric changes, reducing spontaneous action potential firing in sinoatrial node myocytes by 30%.
DOI 10.7554/elife.35753