Chronically elevated FGF23 drives sustained renal ERK signaling and inflammatory transcriptional programs mitigated by cFGF23 gene therapy
A. Salas-Bastos, C. Bardet, K. Kopper, L. Jauze, F. Collaud, A. Francois, G. Chen, M. Mohammadi, C. Stockmann, L. Sommer, J. Loffing, G. Ronzitti, G. Pathare
This study shows that chronic FGF23 elevation causes kidney inflammation via sustained ERK signaling, which is reduced by cFGF23 gene therapy.
bioRxiv · Jan 18, 2024 · PreprintPhysiology