Chronically elevated FGF23 drives sustained renal ERK signaling and inflammatory transcriptional programs mitigated by cFGF23 gene therapy
A. Salas-Bastos, C. Bardet, K. Kopper…·G. Pathare
This study shows that chronic FGF23 elevation causes kidney inflammation via sustained ERK signaling, which is reduced by cFGF23 gene therapy.