G. Chen

Hedgehog Pathway Activity Downstream of Smoothened is regulated specifically by Basal Ciliary PKA

This study investigates how PKA activity in primary cilia regulates the Hedgehog pathway, showing that ciliary PKA specifically modulates the pathway even when cilia are disrupted.

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Size evolution of gigantic genomes suggests stochastic outcomes of transposable element/host silencing interactions

The paper examines TE/host interactions in salamander genomes and finds no correlation between genome size and TE deletion rates or suppression, suggesting stochastic TE accumulation in gigantic genomes.

Mutation of phosphatidate phosphohydrolase genes confers broad-spectrum disease resistance in plants

The paper shows that mutating phosphatidate phosphohydrolase (PAH) genes in rice and Arabidopsis increases phosphatidic acid (PA) levels and broad-spectrum disease resistance.

A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

Myocardial infarction creates a critical time window for AAV gene therapy

This paper shows that myocardial infarction creates a time window where AAV gene therapy is more effective in mice, improving gene expression and therapeutic outcomes when administered three days post-infarction.

Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens

The paper determines crystal structures of a TCR complex with NRAS neoantigens and uses AlphaFold to model these complexes, showing varying success across different implementations.

Cardioprotection by Poloxamer 188 is Mediated through Increased Endothelial Nitric Oxide Production

This study shows that Poloxamer 188 protects against ischemia/reperfusion injury by increasing endothelial nitric oxide production in both cell and rat models.

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

Efficient Gene Editing and Overexpression of Gametophyte Transformation in a Model Fern

This paper develops a CRISPR/Cas9 system for efficient gene editing and overexpression in the fern Ceratopteris richardii, demonstrating functional effects on stomatal and photosynthetic traits.

pH-Sensitive Nanodroplets for Controlled Delivery of Berberine Chloride

This paper develops pH-sensitive nanodroplets for controlled berberine chloride delivery, showing high encapsulation efficiency and ultrasound-enhanced release.

Analyses of Xenorhabdus griffiniae genomes reveal two distinct sub-species that display intra-species variation due to prophages.

This study identifies two subspecies of Xenorhabdus griffiniae and shows that prophages drive intraspecies genomic variation.

PFKP regulates AXL-MET oncogenic and metabolic pathways in lung cancer

This study shows PFKP promotes lung cancer progression by interacting with the AXL-MET pathway, beyond its metabolic role in glycolysis.

Environmental factors and host sex influence the skin microbiome structure of Hong Kong newt (Paramesotriton hongkongensis) in a coldspot of chytridiomycosis in subtropical East Asia

The paper investigates the skin microbiome of Hong Kong newts, finding that environmental factors and host sex influence its composition, with core microbes potentially aiding resistance to chytridiomycosis.

SlWRKY80 recruits SlHDA1 to regulates the tomato fruit ripening and color transformation

This study identifies SlWRKY80's role in tomato fruit ripening and color change by regulating SlSGR1 and SlPSY1 through recruitment of SlHDA1.

Ketone body 3-hydroxybutyrate alleviates CCl4-induced liver fibrosis in mice through regulation of mitochondrial fission and reduction of oxidative stress

This study shows that 3-hydroxybutyrate reduces liver fibrosis in mice by improving mitochondrial function and reducing oxidative stress.

Using split protein reassembly strategy to control PLD enzymatic activity

This study uses split protein reassembly and optogenetic techniques to control PLD enzymatic activity by modulating domain interactions.

Sac1 links phosphoinositide turnover to cryptococcal virulence

This study identifies Sac1 as a key factor in cryptococcal virulence by linking phosphoinositide turnover to host cell uptake and capsule production through genome-scale screening.

Chronically elevated FGF23 drives sustained renal ERK signaling and inflammatory transcriptional programs mitigated by cFGF23 gene therapy

This study shows that chronic FGF23 elevation causes kidney inflammation via sustained ERK signaling, which is reduced by cFGF23 gene therapy.

Exploring information exchange between Thesium chinense and its host Prunella vulgaris through joint transcriptomic and metabolomic analysis

This study identifies 5 transferred metabolites and 668 mobile genes between Thesium chinense and its host Prunella vulgaris, revealing information exchange critical for haustoria formation and parasitism.

Camel milk affects serum metabolites by modulating the intestinal microflora

This study shows that camel milk modulates gut microbiota and serum metabolites in rats, with beneficial bacteria and metabolites resembling those of healthy individuals.

IL-2RαKO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells

The paper investigates IL-2RαKO mice and finds maternal microchimerism contributes to IL-2R expression in vascular smooth muscle cells, revealing IL-2R's role in regulating cell proliferation in non-lymphoid cells.

Protein language models-assisted engineering of Uracil-N glycosylase enables programmable T-to-G and T-to-C base editing

This study uses protein language models to engineer a uracil-N-glycosylase variant for programmable T-to-G and T-to-C base editing, achieving high success rates in correcting genetic mutations in mice.

Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A

This study shows that IgA suppresses epithelial proliferation and tumorigenesis by interacting with DMBT1, highlighting its role in maintaining mucosal homeostasis.

Sustained bacterial (N2O) reduction at acidic pH

The paper identifies a bacterial culture from acidic soil that reduces N2O to N2 at pH 4.5, challenging the assumption that microbial N2O reduction is limited to circumneutral pH.

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

Genetic basis and evolution of structural color polymorphism in an Australian songbird

The paper investigates the genetic basis of melanism in white-winged fairywren subspecies, finding that the mainland blue subspecies re-evolved blue plumage from a black ancestor through genetic changes in ASIP and SCUBE2.

Molecular characterization of baculovirus-induced chromatin marginalization and architectural alteration

This paper identifies the molecular mechanisms of baculovirus-induced chromatin marginalization and structural changes, revealing the role of Lamin A/C-HP1a-H3K9me3 interactions and nuclear F-actin.