Cell BiologybioRxiv
A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC
R. Arce-Molina, F. Cortes-Molina, P. Y. Sandoval…·A. San Martin
The paper introduces PyronicSF, a GFP-based sensor for real-time mitochondrial pyruvate transport, concentration, and flux, revealing the MPC's role in regulating respiration vs. anaplerosis/gluconeogenesis.
DOI 10.7554/elife.53917