Cross-Linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model.
F. Cremasco, E. Menietti, D. Speziale, J. Sam, S. Sammicheli, M. Richard, A. Varol, C. Klein, P. Umana, M. Bacac, S. Colombetti, M. Perro
This study investigates how CD20-TCB induces T cell-tumor synapses and recruitment in a humanized murine model of DLBCL, revealing a triple mechanism involving synapse formation, resident T cell proliferation, and peripheral T cell recruitment.
bioRxiv · Oct 9, 2020Immunology