Author

M. Bacac

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:imaging· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Klein· 2 shared D. Speziale· 2 shared E. Menietti· 2 shared J. Sam· 2 shared M. Perro· 2 shared S. Colombetti· 2 shared T. Fauti· 2 shared A. B. Roth· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

C. Klein

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single-cell characterization of human GBM reveals regional differences in tumor-infiltrating leukocyte activation

P. Schmassmann, J. Roux, S. Dettling, S. Hogan, T. Shekarian, T. A. Martins, M.-F. Ritz, S. Herter, M. Bacac, G. Hutter

The paper uses single-cell RNA sequencing to analyze regional differences in tumor-infiltrating leukocytes in GBM, revealing distinct transcriptional profiles and impaired activation states.

bioRxiv · Jun 17, 2022 · PreprintCancer Biology

Multi-Parameter Quantitative Imaging of Tumor Microenvironments Reveals Perivascular Immune Niches Associated with Anti-Tumor Immunity

C. R. Stoltzfus, R. Sivakumar, L. Kunz, B. E. Olin Pope, E. Menietti, D. Speziale, R. Adelfio, M. Bacac, S. Colombetti, M. Perro, M. Y. Gerner

This study uses spatial analysis to show that perivascular immune niches are associated with anti-tumor immunity and are enhanced by immunotherapy.

bioRxiv · Jun 17, 2021Immunology

Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

L. Cabon, D. Petropolis, W. Tien-Street, P. R. Ng, H. S. Grant, K. Karalis, G. A. Hamilton, J. Sam, T. Weinzierl, T. Fauti, A. Freimoser-Grundschober, J. Eckmann, C. Hage, M. Geiger, V. Micallef, , R. Barrile

The paper demonstrates that human immunocompetent Organs-on-Chips can predict safety liabilities of T-cell bispecific antibodies targeting tumor antigens.

bioRxiv · Feb 22, 2021Cancer Biology

BET Inhibition Enhances TNF Mediated Anti-Tumor Immunity

L. C. Wellinger, S. J. Hogg, D. M. Newman, T. Friess, D. Geiss, J. Michie, K. M. Ramsbottom, M. Bacac, T. Fauti, D. Marbach, L. Jarassier, P. Thienger, A. Paehler, L. A. Cluse, C. J. Kearney, , R. W. Johnstone

This paper identifies BET bromodomain inhibitors as agents that enhance anti-tumor immunity by sensitizing tumors to TNF-mediated cytotoxicity through suppression of NF-κB signaling.

bioRxiv · Feb 15, 2021Cancer Biology

Cross-Linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model.

F. Cremasco, E. Menietti, D. Speziale, J. Sam, S. Sammicheli, M. Richard, A. Varol, C. Klein, P. Umana, M. Bacac, S. Colombetti, M. Perro

This study investigates how CD20-TCB induces T cell-tumor synapses and recruitment in a humanized murine model of DLBCL, revealing a triple mechanism involving synapse formation, resident T cell proliferation, and peripheral T cell recruitment.

bioRxiv · Oct 9, 2020Immunology