Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3-/- mice
F. D. Weiss, Y. Alvarez, A. Sahu, F. Shakeri, H. E. Lee, A.-K. Gellner, A. Buness, E. Latz, F. Meissner
The paper identifies retention of 129S genome in Nlrp3-/- mice causing NLRP1 hypersensitivity and transcriptional changes, and introduces a conditional Nlrp3 allele to resolve phenotypes.
bioRxiv · Jan 3, 2024Immunology