Pharmacology & ToxicologybioRxiv
Dual blockade of misfolded alpha-sarcoglycan degradation by bortezomib and givinostat combination
L. Hoch, N. Bourg, F. Degrugillier…·X. Nissan
This study identifies givinostat as a potential therapeutic for LGMD R3 by inhibiting autophagy and enhancing bortezomib's effect on misfolded alpha-sarcoglycan degradation.
DOI 10.3389/fphar.2022.856804