BiochemistrybioRxiv
Molecular mechanism of Arp2/3 complex inhibition by Arpin
F. E. Fregoso, T. van Eeuwen, G. Simanov…·R. Dominguez
This study determines the cryo-EM structure of Arpin bound to Arp2/3 complex and identifies sequence differences in the C-helix that distinguish inhibition from activation.
DOI 10.1038/s41467-022-28112-2