ER translocation of suboptimal targeting sequences depends on Sec61β/Sbh1 and its phosphorylation
G. Barbieri, J. Simon, C. R. Lupusella, F. Pereira, F. Elia, H. Meyer, M. Schuldiner, S. D. Hanes, D. Nguyen, V. Helms, K. Romisch
The paper shows that phosphorylation of Sbh1 regulates ER translocation of proteins with suboptimal targeting sequences by inducing conformational changes.
bioRxiv · May 18, 2022 · PreprintBiochemistry