J. Simon

Single-cell transcriptomics predict novel potential regulators of acute epithelial restitution in the ischemia-injured intestine

The paper uses single-cell RNA sequencing to identify CSF-1 as a potential regulator of age-dependent intestinal epithelial restitution in a pig model.

Metastatic site influences driver gene function in pancreatic cancer

This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.

Effect of pH on the thermostability and redox properties of cytochrome c552 from Wolinella succinogenes

This study investigates how pH affects the thermostability and redox properties of cytochrome c552 from Wolinella succinogenes, identifying a protonable group influencing its reduction potential.

Alveolar macrophages play a key role in tolerance to ozone

This study identifies alveolar macrophages as critical for ozone tolerance in mice, showing their role in reducing inflammation and injury through suppressed signaling pathways.

Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression

The paper investigates how 9p21.3 deletions in cancer disable both cell intrinsic and extrinsic tumor suppression by co-deleting CDKN2A/B and type I interferons, leading to immune evasion and metastasis.

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease

This study develops somatic mouse models of gastric cancer that replicate human disease subtypes and reveal genotype-specific metastatic patterns and immune interactions.

Identification of novel basil downy mildew resistance genes using de novo comparative transcriptomics

This study identifies novel resistance genes against basil downy mildew using comparative transcriptomics in resistant and susceptible plants.

ER translocation of suboptimal targeting sequences depends on Sec61β/Sbh1 and its phosphorylation

The paper shows that phosphorylation of Sbh1 regulates ER translocation of proteins with suboptimal targeting sequences by inducing conformational changes.

Profiling of the drug resistance of thousands of Src tyrosine kinase mutants uncovers a regulatory network that couples autoinhibition to catalytic domain dynamics

Achieving dendritic cell subset-specific targeting in vivo by site-directed conjugation of targeting antibodies to nanocarriers

This paper develops a site-directed conjugation method to attach antibodies to nanocarriers for specific targeting of dendritic cell subsets in vivo, improving vaccine efficacy by avoiding non-specific uptake.

ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast Cancer

This study identifies ZHX2 as a promoter of HIF1α oncogenic signaling in TNBC, showing its role in cell growth, invasion, and metastasis through interaction with HIF1.

Genetic determinants of risk and survival in pulmonary arterial hypertension

This study identifies common genetic variants associated with pulmonary arterial hypertension risk and survival, focusing on HLA-DPA1/DPB1 and a SOX17 enhancer locus.