Author

K. Romisch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Assay:proteomics· 4 Organism:yeast· 3 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

V. Helms· 3 shared D. Nguyen· 2 shared F. Elia· 2 shared F. Pereira· 2 shared G. Barbieri· 2 shared A. Boergel· 1 shared C. R. Lupusella· 1 shared F. H. Santiago-Tirado· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

V. Helms

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sbh1/Sec61beta is a specific signal peptide receptor within the Sec61 channel

L. Yadhanapudi, M. Lommel, P. Bhadra, G. Barbieri, R. Singh, M. Jung, V. Helms, T. Eisgruber, F. Stengel, A. Boergel, K. Remans, K. Romisch

This study identifies Sbh1/Sec61β as a specific signal peptide receptor that recognizes and guides substrates into the Sec61 channel through its cytosolic IDR and conserved regions.

bioRxiv · Mar 12, 2024 · PreprintBiochemistry

The ER protein translocation channel subunit Sbh1 controls virulence of Cryptococcus neoformans

F. H. Santiago-Tirado, T. Hurtaux, J. Geddes-McAlister, D. Nguyen, V. Helms, T. L. Doering, K. Romisch

This paper shows that Sbh1 in Cryptococcus neoformans regulates virulence by controlling the secretion of virulence factors through the secretory pathway.

bioRxiv · Jun 1, 2022 · PreprintMicrobiology

ER translocation of suboptimal targeting sequences depends on Sec61β/Sbh1 and its phosphorylation

G. Barbieri, J. Simon, C. R. Lupusella, F. Pereira, F. Elia, H. Meyer, M. Schuldiner, S. D. Hanes, D. Nguyen, V. Helms, K. Romisch

The paper shows that phosphorylation of Sbh1 regulates ER translocation of proteins with suboptimal targeting sequences by inducing conformational changes.

bioRxiv · May 18, 2022 · PreprintBiochemistry

Effect of Sec61 interaction with Mpd1 on Endoplasmic Reticulum-Associated Degradation

F. Pereira, M. Rettel, F. Stein, M. M. Savitski, I. Collinson, K. Romisch

The paper identifies Mpd1 as an ERAD factor that interacts with Sec61 and shows that this interaction is required for CPY* ERAD.

bioRxiv · Sep 7, 2018Biochemistry

The N-terminus of Sec61p plays key roles in ER protein import and ERAD

F. Elia, T. Tretter, K. Romisch

This study investigates the role of the N-terminus of Sec61p in ER protein import and ERAD by mutating its acetylation site and amphipathic helix in yeast.

bioRxiv · Feb 5, 2018Biochemistry