H. Meyer

A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes

The paper uses a bi-genomic split-GFP assay to identify mitochondrial matrix and inner membrane proteins, revealing 50 previously unvisualized proteins and characterizing dually localized proteins.

The antifungal activity of cymoxanil is associated with proton pump inhibition and disruption of plasma membrane potential

This study investigates the antifungal mechanism of cymoxanil, finding it disrupts plasma membrane potential and inhibits proton pumps in yeast, suggesting a mode of action involving membrane transport and acidification.

Structural basis of ubiquitin-independent PP1 complex disassembly by p97

This study presents cryo-EM structures of p97 disassembling a PP1 complex by stripping off an inhibitory subunit, revealing how the complex is arranged and extracted through the p97 channel.

ER translocation of suboptimal targeting sequences depends on Sec61β/Sbh1 and its phosphorylation

The paper shows that phosphorylation of Sbh1 regulates ER translocation of proteins with suboptimal targeting sequences by inducing conformational changes.

Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution

The paper systematically analyzes membrane contact sites in yeast to identify new proteins involved in lipid distribution.

Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis

The paper shows that a high fat diet reduces MHC-II expression in intestinal stem cells, promoting tumorigenesis by altering immune recognition.

Structural fuzziness of the RNA-organizing protein SERF1a determines a toxic gain-of-interaction

This study identifies SERF1a as an RNA-organizing protein with structural fuzziness that enables toxic interactions with alpha-Synuclein, contributing to neurodegenerative disease mechanisms.