Structural fuzziness of the RNA-organizing protein SERF1a determines a toxic gain-of-interaction
F. Falsone, H. Meyer, H. Dellago, C. Tam-Amersdorfer, D. Merle, R. Parlato, B. Gesslbauer, J. Almer, M. Gschwandtner, A. Leon, T. Franzmann, J. Grillari, A. Kungl, K. Zangger
This study identifies SERF1a as an RNA-organizing protein with structural fuzziness that enables toxic interactions with alpha-Synuclein, contributing to neurodegenerative disease mechanisms.
bioRxiv · Jul 24, 2019Biochemistry