BiochemistrybioRxiv
Structural fuzziness of the RNA-organizing protein SERF1a determines a toxic gain-of-interaction
F. Falsone, H. Meyer, H. Dellago…·K. Zangger
This study identifies SERF1a as an RNA-organizing protein with structural fuzziness that enables toxic interactions with alpha-Synuclein, contributing to neurodegenerative disease mechanisms.
DOI 10.1016/j.jmb.2019.11.014