Author

D. Merle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

A. Armento· 1 shared A. Kungl· 1 shared A. Leon· 1 shared B. Gesslbauer· 1 shared B. Trentin· 1 shared C. Bertrand-Gaday· 1 shared C. Tam-Amersdorfer· 1 shared E. Kilger· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperImmunology

A. Armento

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CFH loss in human RPE cells leads to inflammation and complement system dysregulation via the NF-B pathway

A. Armento, T. L. Schmidt, I. Sonntag, D. Merle, M.-a. Jarboui, E. Kilger, S. J. Clark, M. Ueffing

This study shows that loss of CFH in RPE cells increases inflammation and disrupts complement regulation via the NF-κB pathway, contributing to AMD pathology.

bioRxiv · Apr 19, 2021Immunology

Extracellular vesicle-based vaccine platform displaying native viral envelope proteins elicits a robust anti-SARS-CoV-2 response in mice.

K. Polak, N. Greze, M. Lachat, D. Merle, S. Chiumento, C. Bertrand-Gaday, B. Trentin, R. Z. Mamoun

This study develops an EV-based vaccine platform that displays native SARS-CoV-2 Spike proteins, inducing strong anti-viral responses in mice without adjuvants.

bioRxiv · Oct 28, 2020 · PreprintImmunology

Structural fuzziness of the RNA-organizing protein SERF1a determines a toxic gain-of-interaction

F. Falsone, H. Meyer, H. Dellago, C. Tam-Amersdorfer, D. Merle, R. Parlato, B. Gesslbauer, J. Almer, M. Gschwandtner, A. Leon, T. Franzmann, J. Grillari, A. Kungl, K. Zangger

This study identifies SERF1a as an RNA-organizing protein with structural fuzziness that enables toxic interactions with alpha-Synuclein, contributing to neurodegenerative disease mechanisms.

bioRxiv · Jul 24, 2019Biochemistry