J. Grillari

Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification

This paper introduces a Snorkel-tag system for affinity purification of extracellular vesicles using CD81 fused with tags and transmembrane domains, enabling non-destructive isolation and future applications in tracing and analyzing EVs.

The p-rpS6-zone delineates wounding response and the healing process

The paper identifies a p-rpS6-zone around wounds that marks the healing process and shows its role in tissue repair.

Development of a multi-sensor integrated midbrain organoid-on-a-chip platform for studying Parkinson's disease

This study develops a multi-sensor organ-on-a-chip platform to monitor Parkinson's disease-related phenotypes in midbrain organoids and demonstrates its utility in drug screening.

Interplay between mitochondria and reactive oxygen and nitrogen species in metabolic adaptation to hypoxia in facioscapulohumeral muscular dystrophy: potential therapeutic targets.

This paper investigates how mitochondrial reactive oxygen and nitrogen species (RONS) metabolism contributes to oxidative stress in FSHD, showing that mitochondria-targeted antioxidants are more effective in rescuing pathology.

The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans

This study identifies NSUN-1 as an enzyme that methylates rRNA at position C2982 in C. elegans, showing that its depletion affects healthspan, oogenesis, and cuticle integrity.

Structural fuzziness of the RNA-organizing protein SERF1a determines a toxic gain-of-interaction

This study identifies SERF1a as an RNA-organizing protein with structural fuzziness that enables toxic interactions with alpha-Synuclein, contributing to neurodegenerative disease mechanisms.