Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies
M. Scherer, C. Read, G. Neusser, C. Kranz, R. Müller, F. Full, S. Woerz, A. Reichel, E.-M. Schilling, P. Walther, T. Stamminger
The paper shows that dual interferon and DNA damage signaling leads to the formation of giant PML nuclear bodies that trap viral genomes and capsids, providing a multilayered antiviral defense.
bioRxiv · Aug 24, 2021Microbiology