S. Walter

The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins.

The paper determines the cryo-EM structure of the SPT-Orm2 complex and shows Orm2 has higher inhibitory potential than Orm1, despite similar structures.

Ventilation does not affect influenza virus transmission efficiency in a ferret playpen setup

This study shows that ventilation rates do not affect influenza virus transmission efficiency in a ferret playpen setup with close-range interactions and fomites.

Structure of the yeast ceramide synthase

This study determines the structure of the yeast ceramide synthase complex using cryo-EM, revealing its active state and inhibition mechanism by fumonisin B1.

Structure of the endosomal CORVET tethering complex

The paper solves the structure of the CORVET tethering complex using cryo-EM and explains its role in promoting endosome fusion through interactions with Rab5 and PI3P.

Complex Sphingolipid Profiling and Identification of an Inositol Phosphorylceramide Synthase in Dictyostelium discoideum

This study identifies an inositol phosphorylceramide synthase in Dictyostelium discoideum, revealing its sphingolipid biosynthesis pathway and localization.

Utilizing a nanobody recruitment approach for assessing serine palmitoyltransferase activity in ER sub-compartments of yeast.

The paper develops a nanobody recruitment system to measure SPT activity in yeast ER sub-compartments, identifying two distinct active SPT pools.

Structure of the ceramide-bound SPOTS complex

The paper reports cryo-EM structures of the yeast SPT complex with Tsc3, Orm1, and Sac1, revealing ceramide-dependent inhibition and co-regulation of sphingolipid and sterol metabolism.

Streetlights affect moth orientation beyond flight-to-light behaviour

This study shows streetlights disrupt moth orientation beyond flight-to-light behavior, affecting movement patterns and potentially ecosystem services.

Honey Bees Get Map Coordinates from the Dance

This study shows honeybees use the waggle dance to obtain both a flying direction and a map-like coordinate system to locate food sources.

Low membrane fluidity triggers lipid phase separation and protein segregation in vivo

The paper shows that low membrane fluidity in bacteria triggers lipid phase separation and protein segregation without disrupting membrane function.

A yeast lysosomal biogenesis map uncovers the cargo spectrum of lysosomal protein targeting pathways

The paper generates a lysosomal biogenesis map in yeast by combining proteomics and mutant analyses, revealing cargo-receptor relationships and novel CVT pathway cargo.

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression

This study shows herpesviruses induce DUX4 expression, which drives viral gene expression by mimicking embryonic genome activation.

Phosphorylation of the GARP Subunit Vps53 by Snf1 Leads to the Formation of a Golgi-Mitochondria Contact Site (GoMiCS) in Yeast

Independent origin of MIRNA genes controlling homologous target genes by partial inverted duplication of antisense-transcribed sequences

The paper investigates the convergent evolution of two MIR gene families, showing they originated independently through partial inverted duplication of antisense-transcribed sequences targeting MADS-box genes.