PKA drives paracrine crisis and WNT4-dependent testis tumor in Carney complex
C. Djari, I. Sahut-Barnola, A. Septier, I. Plotton, N. Montanier, D. Dufour, A. Levasseur, J. Wilmouth, J.-C. Pointud, F. Faucz, C. Kamilaris, A.-G. Lopez, F. Guillou, A. Swain, S. J. Vainio, , A. M. Lefrancois-Martinez
The paper investigates the role of PKA in Carney complex testis tumors, showing that Prkar1a mutations in both stromal and Sertoli cells drive LCCSCTs via WNT4-dependent paracrine signaling.
bioRxiv · Dec 21, 2020 · PreprintPathology