F. Hashmi

V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is aPhenotypic Driver of Lysosome Dysfunction in Replicative Aging

This study shows that V-ATPase disassembly in yeast aging cells leads to lysosome dysfunction and shorter lifespan, which can be reversed by caloric restriction.

IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers

This study shows that adding intrinsically disordered regions (IDRs) to CARs improves their cytotoxicity against low-antigen cancers by enhancing signaling and killing activity.