The prostate cancer therapy enzalutamide compared with abirateroneacetate/prednisone impacts motivation for exploration, spatial learning andalters dopaminergic transmission in aged castrated mice
C. Nicola, M. Dubois, C. Campart, T. Al Sagheer, L. Desrues, D. Schapman, l. Galas, M. Lange, F. Joly, H. Castel
This study compares the effects of enzalutamide and abiraterone acetate/prednisone on cognitive and dopaminergic functions in aged castrated mice, finding ENZ reduces exploratory behavior and dopaminergic activity.
bioRxiv · Apr 1, 2021Animal Behavior & Cognition