M. Lange

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly

This study identifies CLCC1 as a regulator of hepatic neutral lipid flux and nuclear pore complex assembly through CRISPR screens and functional analyses.

Plant species richness and the root economics space drive soil fungal communities

The paper shows that plant species richness and root economics space axes influence soil fungal community composition in a grassland experiment.

Delay of innate immune responses following influenza B virus infection affects the development of robust antibody response in ferrets

This study shows that delayed innate immune responses to influenza B virus in ferrets lead to weaker antibody responses compared to influenza A virus.

Modelling the transmission and spread of yellow fever in forest landscapes with different spatial configurations

This paper develops a hybrid model to simulate yellow fever virus spread in different forest landscapes and finds that highly fragmented landscapes facilitate faster virus percolation.

Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis

This study identifies structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis, with FSEN1 showing potent on-target inhibition and synergy with ferroptosis inducers.

Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I / Rho-GTPase signaling

A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2

The paper shows cell cycle arrest increases sensitivity to GPX4 inhibitor-induced ferroptosis via elevated oxidizable phospholipids and reduced EMP2 expression.

ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

The paper identifies a stem-like proliferative state in prostate epithelial cells driven by ERG activation, which transitions to luminal cells and is associated with specific chromatin states.

Selenium reduction of ubiquinone via SQOR suppresses ferroptosis

The paper shows selenium reduces ubiquinone to ubiquinol via SQOR, protecting against ferroptosis independently of selenoprotein production.

Uptake of plant-derived carbon and proximity to the root determine differences in temporal and spatial stability among microbial groups

The paper examines how microbial groups differ in temporal and spatial stability of biomass and carbon uptake, finding bacterial stability is higher than fungal, and proximity to roots and symbiotic status influence carbon uptake patterns.

Plant diversity stabilizes soil temperature

This study shows plant diversity stabilizes soil temperature by increasing organic carbon and leaf area index, with effects strengthening over time and under extreme conditions.

A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity

This study uses a CRISPR screen to identify genetic factors affecting cancer cell resistance to C6-ceramide, revealing a role for plasma membrane asymmetry in ceramide toxicity.

Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation

The paper uses CRISPR-Cas9 screens to identify genes regulating PLIN2 and lipid droplet abundance, revealing new mechanisms and creating a resource for lipid metabolism research.

Epilipidomics platform for holistic profiling of oxidized complex lipids in blood plasma of obese individuals

The paper develops an epilipidomics platform to profile oxidized complex lipids in blood plasma of obese individuals and identifies metabolic disorder-related lipid modification signatures.

Myth-busting the provider-user relationship for digital sequence information

This study examines the provider-user relationship for digital sequence information (DSI) and finds that the assumed flow of access and use is more complex than previously thought.

The prostate cancer therapy enzalutamide compared with abirateroneacetate/prednisone impacts motivation for exploration, spatial learning andalters dopaminergic transmission in aged castrated mice

This study compares the effects of enzalutamide and abiraterone acetate/prednisone on cognitive and dopaminergic functions in aged castrated mice, finding ENZ reduces exploratory behavior and dopaminergic activity.

Identification of a Nervous System Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for Neural Crest Regulators EGR2 and SOX2 in Tumorigenesis

RNA-Sequencing of Long-Term Label-Retaining Colon Cancer Stem Cells Identifies Novel Regulators of Quiescence

The paper identifies novel regulators of quiescence in colon cancer stem cells using RNA-sequencing and shows their potential as therapeutic targets.

AdipoAtlas: A Reference Lipidome for Human White Adipose Tissue

The paper presents AdipoAtlas, a reference lipidome of human white adipose tissue, identifying lipid remodeling in lean and obese individuals.

Nutrient Source and Mycorrhizal Association jointly alters Soil Microbial Communities that shape Plant-Rhizosphere-Soil Carbon-Nutrient Flows

This study traces carbon and nitrogen flows in soil microbial communities influenced by plant-AMF associations and substrate types, revealing how these interactions affect decomposition and nutrient cycling.

Phytoplankton thermal responses adapt in the absence of hard thermodynamic constraints

This study analyzes phytoplankton thermal performance curves to assess the role of thermodynamic constraints in their evolution, finding weak constraints and significant phylogenetic adaptation.

The results of biodiversity-ecosystem functioning experiments are realistic

This paper compares biodiversity experiments to real-world plant communities and finds that experimental results are robust to the inclusion of unrealistic communities.

Functional composition rather than species richness drive carbon gain and allocation in experimental grasslands

The paper investigates how functional composition, not species richness, influences carbon gain and allocation in grasslands using 13CO2 labeling.

Genotypic variability enhances the reproducibility of an ecological study

This study tests whether introducing genotypic variability improves reproducibility in ecological experiments across multiple labs, finding it increases consistency in controlled environments but not in variable ones.