Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage
A. Goetz, N. Mylonas, P. Hoegel, M. Silber, H. Heinel, S. Menig, A. Vogel, H. Freyrer, D. Huster, B. Luy, D. Langosch, C. Scharnagl, C. Muhle-Goll, F. Kamp, H. Steiner
The paper shows that altering the flexibility of a di-glycine hinge in the APP transmembrane domain affects γ-secretase cleavage and specificity.
bioRxiv · Nov 20, 2018Biophysics