Author

A. Goetz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:mechanistic / dynamical model· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

C. Scharnagl· 2 shared A. Vogel· 1 shared A.-C. Reymann· 1 shared B. Finan· 1 shared B. Luy· 1 shared C. Muhle-Goll· 1 shared C. Weber· 1 shared D. Huster· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

C. Scharnagl

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multiscale characterization of Caenorhabditis elegans mutants to probe functional mechanisms of human actin pathological variants

T. Hecquet, N. Arbogast, D. Suhner, A. Goetz, G. Amann, S. Yürekli, F. Marangoni, S. Quintin, J. N. Greve, N. Di Donato, A.-C. Reymann

The paper uses C. elegans actin mutants to study human actinopathies, finding that mutation severity correlates with phenotypic defects in the worm model.

bioRxiv · Jul 22, 2024Cell Biology

GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight in obese mice

S. Sachs, A. Goetz, B. Finan, R. D. DiMarchi, Y. Doering, C. Weber, M. Tschoep, T. D. Mueller, S. M. Hofmann

This study shows that GIP receptor agonism reduces dyslipidemia and atherosclerosis in obese mice without affecting body weight.

bioRxiv · Mar 15, 2022 · PreprintPharmacology & Toxicology

Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage

A. Goetz, N. Mylonas, P. Hoegel, M. Silber, H. Heinel, S. Menig, A. Vogel, H. Freyrer, D. Huster, B. Luy, D. Langosch, C. Scharnagl, C. Muhle-Goll, F. Kamp, H. Steiner

The paper shows that altering the flexibility of a di-glycine hinge in the APP transmembrane domain affects γ-secretase cleavage and specificity.

bioRxiv · Nov 20, 2018Biophysics

Dissecting Conformational Changes in APP’s Transmembrane Domain Linked to ε-Efficiency in Familial Alzheimer’s Disease

A. Goetz, C. Scharnagl

This study uses molecular dynamics simulations to analyze how FAD mutations in APP's TMD affect a-secretase cleavage efficiency by altering local and global structural dynamics.

bioRxiv · Feb 22, 2018Biophysics