BiophysicsbioRxiv
Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage
A. Goetz, N. Mylonas, P. Hoegel…·H. Steiner
The paper shows that altering the flexibility of a di-glycine hinge in the APP transmembrane domain affects γ-secretase cleavage and specificity.
DOI 10.1016/j.bpj.2019.04.030