SHORT-TERM CALORIC RESTRICTION IN MICE PROMOTES RESOLUTION OF ATHEROSCLEROSIS, WHILE WEIGHT REGAIN ACCELERATES ITS PROGRESSION
B. Scolaro, E. J. Brown, F. Krautter, M. Petitjean, C. Donahoe, S. Pena, M. L. Garabedian, C. A. Nikain, M. Laskou, O. Tufanli, C. Hannemann, M. Aouadi, A. Weinstock, E. Fisher
This study shows that short-term caloric restriction in mice reduces atherosclerosis by promoting Fcgr4+ macrophages, while weight regain accelerates plaque progression by eliminating these cells and reprogramming immune progenitors.
bioRxiv · May 7, 2023 · PreprintImmunology