F. Spill

P53 Orchestrates Cancer Metabolism: Unveiling Strategies to Reverse the Warburg Effect

This study develops a mathematical model of p53's role in reversing the Warburg effect by modulating cancer metabolism, showing that p53 activation can restore OXPHOS and that targeting glycolysis may be more effective than targeting SCO2 in p53-mutated cancers.

Interplay of p53 and XIAP protein dynamics orchestrates cell fate in response to chemotherapy

This study models the interplay between p53 and XIAP dynamics to predict chemotherapy response, finding that XIAP induction rate, not p53 concentration, determines cell fate.

Discretised flux balance analysis for reaction-diffusion simulation of single-cell metabolism

This paper develops a spatial flux balance analysis method to simulate single-cell metabolism by incorporating diffusion effects across a grid-based system.

A mechanical modelling framework to study endothelial permeability

This paper presents a mechanical modelling framework to study endothelial permeability by simulating VE-cadherin bonds and their response to mechanical and chemical stimuli.

Mathematical reconstruction of the metabolic network in an in-vitro multiple myeloma model.

This paper develops an in-silico metabolic model of a co-culture system to better understand tumor metabolism and its interactions with surrounding cells.

Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy - an in-silico study

This study uses computational modeling to show that disorganized mitochondrial and myofibrillar arrangement in diabetic cardiomyocytes leads to spatial variation in ADP/ATP ratios and increased inorganic phosphate concentration.

Modeling the three-way feedback between cellular contractility, actin polymerization, and adhesion turnover resolves the contradictory effects of RhoA and Rac1 on endothelial junction dynamics

This study develops a chemo-mechanical model to explain how RhoA and Rac1 differentially affect endothelial junction dynamics through their roles in contractility, adhesion turnover, and actin polymerization.

CASTLE: Cell Adhesion with Supervised Training and Learning Environment

CASTLE automates cell counting and morphology analysis in phase-contrast microscopy images using machine learning, showing differences in leukocyte adhesion caused by Galectin-9.

Balance of Mechanical Forces Drives Endothelial Gap Formation and May Facilitate Cancer and Immune-Cell Extravasation

This study shows that mechanical forces drive spontaneous gap formation in endothelial cells, which may facilitate cancer and immune cell extravasation by preferentially occurring at cell vertices.

The impact of tumor stromal architecture on therapy response and clinical progression

This paper investigates how tumor stromal architecture influences therapy response and resistance in lung, breast, and kidney cancers using mathematical models, experimental studies, and clinical analysis.