Conjugates of neuroprotective chaperone L-PGDS provide MRI contrast for detection of amyloid β-rich regions in live Alzheimer's Disease mouse model brain
B. Sharma, J. Grandjean, M. Phillips, A. Kumar, F. Mandino, L.-Y. Yeow, V. Nandwana, V. P. Dravid, X. Bengang, S. Lim, K. Pervushin
This study conjugates the neuroprotective chaperone L-PGDS with magnetic nanoparticles to enhance MRI contrast for detecting amyloid β-rich regions in Alzheimer's Disease mouse models.
bioRxiv · Mar 8, 2020Biochemistry