M. Phillips

Metabolic immaturity of newborns and breast milk bile acids are the central determinants of heightened neonatal vulnerability to norovirus diarrhea

This study identifies metabolic immaturity in newborns and maternal bile acids in breast milk as key factors increasing vulnerability to norovirus diarrhea.

Deep3DSIM: Super-resolution imaging of thick tissue using 3D structured illumination with adaptive optics

This paper introduces Deep3DSIM, an upright 3D-SIM system with adaptive optics for deep tissue imaging, achieving high-quality imaging up to 130 micrometers in Drosophila brain.

Clinically relevant orthotopic pancreatic cancer models for adoptive T cell therapy

This study compares two orthotopic PDAC mouse models to evaluate their suitability for studying adoptive T cell therapy, finding that the MT-5 model better replicates the stromal features of human PDAC.

Impact of combinatorial histone modifications on acetyllysine recognition by the ATAD2 and ATAD2B bromodomains

This study investigates how ATAD2 and ATAD2B bromodomains recognize acetylated lysine on histones in the presence of other modifications, revealing distinct binding modes and mechanisms.

Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum

This study investigates the binding specificity of PfBDP1 bromodomain to acetylated histones in P. falciparum, revealing its preference for tetra-acetylated H4 and potential therapeutic implications.

Combining metabolomics and experimental evolution reveals key mechanisms underlying longevity differences in laboratory evolved Drosophila melanogaster populations

The paper combines metabolomics and experimental evolution to identify genetic and physiological mechanisms underlying longevity differences in Drosophila melanogaster populations.

Coordination of di-acetylated histone ligands by the ATAD2 bromodomain

This study identifies how the ATAD2 bromodomain recognizes di-acetylated histone tails through residue-specific interactions and confirms its monomeric state using biophysical techniques.

Hematopoietic stem cell requirement for macrophage regeneration is tissue-specific

The paper shows that hematopoietic stem cells (HSCs) are required for regeneration of peritoneal macrophages but not brain microglia.

Structural Characteristics and Proton Conductivity of the Gel Within the Electrosensory Organs of Cartilaginous Fishes

This study describes the structural characteristics and proton conductivity of gel in cartilaginous fish electrosensory organs using microscopy, x-ray scattering, and enzymatic digestion.

Structural insights into the recognition of mono- and di-acetylated histones by the ATAD2B bromodomain

This study investigates the ligand specificity of the ATAD2B bromodomain, showing it binds mono- and di-acetylated histones and identifies structural features critical for this recognition.

Conjugates of neuroprotective chaperone L-PGDS provide MRI contrast for detection of amyloid β-rich regions in live Alzheimer's Disease mouse model brain

This study conjugates the neuroprotective chaperone L-PGDS with magnetic nanoparticles to enhance MRI contrast for detecting amyloid β-rich regions in Alzheimer's Disease mouse models.

The BRPF1 bromodomain is a molecular reader of di-acetyllysine

This study identifies the BRPF1 bromodomain as a selective reader of di-acetyllysine modifications on histone H4 and characterizes its binding preferences and mechanisms.

Regulation of KRAS4A/B splicing in cancer stem cells by the RBM39 splicing complex.

This study identifies KRAS4A and KRAS4B splice isoforms with distinct expression patterns in cancer stem cells and shows that targeting KRAS4A splicing is a potential therapeutic strategy in KRAS mutant tumors.

Comprehensive analysis of the internal structure and firmness in American cranberry (Vaccinium macrocarpon Ait.) fruit

This study develops a high-throughput computer-vision method to analyze cranberry internal structure and its correlation with fruit firmness across 16 cultivars over 40 days.

Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria

This paper determines the structure of TagA, a glycosyltransferase involved in wall teichoic acid biosynthesis, and reveals its mechanism of catalysis and regulation by membrane interactions.